{"id":276,"date":"2020-04-09T01:09:19","date_gmt":"2020-04-08T23:09:19","guid":{"rendered":"https:\/\/bioinfo.imdik.pan.pl\/?page_id=276"},"modified":"2020-08-28T13:57:38","modified_gmt":"2020-08-28T11:57:38","slug":"project-atlas-covid-19","status":"publish","type":"page","link":"https:\/\/bioinfo.imdik.pan.pl\/index.php\/project-atlas-covid-19\/","title":{"rendered":"Project: ATLAS-COVID-19"},"content":{"rendered":"\n<p class=\"has-text-align-center has-text-color\" style=\"color:#b00003\"><strong>&gt;&gt;&gt; UNDER DEVELOPMENT &lt;&lt;&lt;<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Project title: <\/strong><\/h3>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size\"><strong>Creating an atlas of interactions of bioactive compounds and peptides with the proteins and glycoproteins of the 2019-nCOV virus as well as with the human ACE2 protein, and the design of new inhibitors with potential activity against COVID-19<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Research\ngroups: <\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>Bioinformatics Laboratory, Mossakowski Medical Research Centre Polish Academy of Sciences<\/li><li>Laboratory of Molecular Design and Bioinformatics, Faculty of Physics, University of Warsaw<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Preliminary\nresearch: <\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>P. Grieb and B. Lesyng, &#8220;<strong><a href=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/Understand_the_Coronawirus_PG_and_BL_20_03_2020.pdf\"><em>Understanding the coronavirus<\/em><\/a>&#8220;<\/strong>, (report in a form of presentation), Warsaw 20.03.2020.<\/li><li>K. A. Krzy\u015bko, L.Charzewski, P. Chy\u017cy, M. Koli\u0144ski, B. Lesyng, &#8220;<strong><em><a href=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/Report_1_work_in_progress.pdf\">Interactions of drug-set-1 and drug-set-2 with 3CL protease<\/a><\/em><\/strong>&#8220;, Warsaw, 04.2020.<\/li><li>\u0141. Charzewski, &#8220;<strong><em><a href=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/DrugBank-Screening-for-3CL-inhibitors.pdf\">DrugBank Screening for 3CL inhibitors<\/a><\/em><\/strong>&#8220;.<\/li><li>Julia Bartkowska, Daria Kaminska, Mateusz Zalewski, <a href=\"https:\/\/bioinfo.imdik.pan.pl\/coronavirus-service\/\"><strong><em>CORONAVIRUS WEB SERVICE<\/em><\/strong><\/a>, (information about the coronavirus pandemic &#8211; only in Polish).<\/li><li>The binding energy of 10 antiviral drugs in complex with SARS-CoV-2 protease:<\/li><\/ul>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/t.png\" alt=\"\" class=\"wp-image-281\" width=\"396\" height=\"305\"\/><\/figure><\/div>\n\n\n\n<ul class=\"wp-block-list\"><li>Binding poses of 4 antiviral drugs (brecanavir, lopinavir, nelfinavir and saquinavir) in complex with &nbsp;SARS-CoV-2 protease:<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-table is-style-stripes\">\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-282\" src=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/1.jpg\" alt=\"\" width=\"653\" height=\"444\" srcset=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/1.jpg 653w, https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/1-300x204.jpg 300w\" sizes=\"auto, (max-width: 653px) 100vw, 653px\" \/><\/td>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-294\" src=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/2.jpg\" alt=\"\" width=\"653\" height=\"444\" srcset=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/2.jpg 653w, https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/2-300x204.jpg 300w\" sizes=\"auto, (max-width: 653px) 100vw, 653px\" \/><\/td>\n<\/tr>\n<tr>\n<td><strong>brecanavir<\/strong><\/td>\n<td><strong>lopinavir<\/strong><\/td>\n<\/tr>\n<tr>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-298\" src=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/3.jpg\" alt=\"\" width=\"653\" height=\"444\" srcset=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/3.jpg 653w, https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/3-300x204.jpg 300w\" sizes=\"auto, (max-width: 653px) 100vw, 653px\" \/><\/td>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-299\" src=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/4.jpg\" alt=\"\" width=\"653\" height=\"444\" srcset=\"https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/4.jpg 653w, https:\/\/bioinfo.imdik.pan.pl\/wp-content\/uploads\/2020\/04\/4-300x204.jpg 300w\" sizes=\"auto, (max-width: 653px) 100vw, 653px\" \/><\/td>\n<\/tr>\n<tr>\n<td><strong>nelfinavir<\/strong><\/td>\n<td><strong>saquinavir<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<\/div><\/div>\n\n\n\n<p><\/p>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&gt;&gt;&gt; UNDER DEVELOPMENT &lt;&lt;&lt; Project title: Creating an atlas of interactions of bioactive compounds and peptides with the proteins and glycoproteins of the 2019-nCOV virus as well as with the human ACE2 protein, and the design of new inhibitors with &hellip; <a href=\"https:\/\/bioinfo.imdik.pan.pl\/index.php\/project-atlas-covid-19\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"onecolumn-page.php","meta":{"footnotes":""},"class_list":["post-276","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bioinfo.imdik.pan.pl\/index.php\/wp-json\/wp\/v2\/pages\/276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioinfo.imdik.pan.pl\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bioinfo.imdik.pan.pl\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bioinfo.imdik.pan.pl\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/bioinfo.imdik.pan.pl\/index.php\/wp-json\/wp\/v2\/comments?post=276"}],"version-history":[{"count":73,"href":"https:\/\/bioinfo.imdik.pan.pl\/index.php\/wp-json\/wp\/v2\/pages\/276\/revisions"}],"predecessor-version":[{"id":483,"href":"https:\/\/bioinfo.imdik.pan.pl\/index.php\/wp-json\/wp\/v2\/pages\/276\/revisions\/483"}],"wp:attachment":[{"href":"https:\/\/bioinfo.imdik.pan.pl\/index.php\/wp-json\/wp\/v2\/media?parent=276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}